FXYD2 Antibody (1C3-B3)

Novus Biologicals, part of Bio-Techne | Catalog # H00000486-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Sandwich ELISA Capture, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 1C3-B3

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FXYD2 Antibodies »

Product Specifications

Immunogen

FXYD2 (AAH05302.1, 1 a.a. ~ 64 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MDRWYLGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP

Specificity

FXYD2 - FXYD domain containing ion transport regulator 2

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for FXYD2 Antibody (1C3-B3)

Western Blot: FXYD2 Antibody (1C3-B3) [H00000486-M01]

Western Blot: FXYD2 Antibody (1C3-B3) [H00000486-M01]

Western Blot: FXYD2 Antibody (1C3-B3) [H00000486-M01] - FXYD2 monoclonal antibody (M01), clone 1C3-B3 Analysis of FXYD2 expression in Jurkat.
Immunohistochemistry-Paraffin: FXYD2 Antibody (1C3-B3) [H00000486-M01]

Immunohistochemistry-Paraffin: FXYD2 Antibody (1C3-B3) [H00000486-M01]

Immunohistochemistry-Paraffin: FXYD2 Antibody (1C3-B3) [H00000486-M01] - Analysis of monoclonal antibody to FXYD2 on formalin-fixed paraffin-embedded human salivary gland. Antibody concentration 3 ug/ml.
Sandwich ELISA Capture: FXYD2 Antibody (1C3-B3) [H00000486-M01]

Sandwich ELISA Capture: FXYD2 Antibody (1C3-B3) [H00000486-M01]

Sandwich ELISA Capture: FXYD2 Antibody (1C3-B3) [H00000486-M01] - Detection limit for recombinant GST tagged FXYD2 is 0.3 ng/ml as a capture antibody.

Applications for FXYD2 Antibody (1C3-B3)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Sandwich ELISA

1:100-1:2000

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: FXYD2

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Long Name

Sodium/potassium-transporting ATPase subunit gamma

Alternate Names

ATP1C, ATP1G1

Entrez Gene IDs

486 (Human)

Gene Symbol

FXYD2

OMIM

154020 (Human)

UniProt

AAH05302 (Human)

Additional FXYD2 Products

Product Documents for FXYD2 Antibody (1C3-B3)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FXYD2 Antibody (1C3-B3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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