FXYD2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49574

Novus Biologicals, part of Bio-Techne
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NBP2-49574
NBP2-49574-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FXYD2 Antibodies »

Product Summary for FXYD2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SRRFRCGGNKKRRQINEDEP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FXYD2 Antibody

Immunohistochemistry-Paraffin: FXYD2 Antibody [NBP2-49574]

Immunohistochemistry-Paraffin: FXYD2 Antibody [NBP2-49574]

Immunohistochemistry-Paraffin: FXYD2 Antibody [NBP2-49574] - Staining of human kidney shows strong membranous positivity in cells in tubules.

Applications for FXYD2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FXYD2

FXYD2 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme's activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Long Name

Sodium/potassium-transporting ATPase subunit gamma

Alternate Names

ATP1C, ATP1G1

Gene Symbol

FXYD2

Additional FXYD2 Products

Product Documents for FXYD2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for FXYD2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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