G0S2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-71690

Novus Biologicals, part of Bio-Techne
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NBP1-71690
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.56 mg/ml

View all G0S2 Antibodies »

Product Summary for G0S2 Antibody

Immunogen

A genomic peptide made to the human G0S2 protein (residues 1-103). [Swiss-Prot P27469]

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for G0S2 Antibody

Immunocytochemistry/ Immunofluorescence: G0S2 Antibody [NBP1-71690]

Immunocytochemistry/ Immunofluorescence: G0S2 Antibody [NBP1-71690]

Immunocytochemistry/Immunofluorescence: G0S2 Antibody [NBP1-71690] - GOS2 antibody was tested at 1:50 in A431 cells with FITC (green). Nuclei were counterstained with Dapi (blue).

Applications for G0S2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:100
Application Notes
This G0S2 antibody is useful in ICC/IF.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 0.1% BSA, and 50% Glycerol

Preservative

0.05% Sodium Azide

Concentration

0.56 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: G0S2

G0S2 (G0/G1 switch protein 2) was discovered in lectin activated lymphocytes during G0 to G1 transition favoring cell division and postulated to regulate G0/G1 phase either by releasing lymphocytes from quiescence (G0 to G1 transition) or via promoting proliferation (G1 to S phase transition). Subsequently, this multifaceted protein was documented to implicate in proliferation, metabolism, inflammation, and carcinogenesis. In mouse, G0S2 was shown to express in adipose tissue and its direct up-regulation by PPAR-gamma was associated with cell-cycle withdrawal, growth arrest and adipogenic differentiation of preadipocytes. G0S2 has been proposed to inhibit hematopoietic stem cell proliferation and to promote stem cell quiescence (G0 phase). G0S2 features a CpG-rich island that potentially allows for germ-line expression and its promoter region contains binding sites for transcription factors AP1, AP2, AP3, NFAT and sequence motifs which responds to transcriptional activation stimulated by lectin, retinoic acid, PPARs agonists, glucose and insulin. G0S2 is epigenetically silenced in head/neck and squamous lung cancer, and cisplatin-resistant cancer cells advocating for its role in tumorigenesis and chemoresistance. G0S2 expression is elevated in endometriosis, bronchial epithelial cells treated with retinoic acid, senescent dermal fibroblasts, BM cells from patients with rheumatoid arthritis, and peripheral mononuclear cells from patients with vasculitis and psoriasis.

Alternate Names

G0/G1 switch regulatory protein 2, G0/G1switch 2, RP1-28O10.2

Entrez Gene IDs

50486 (Human)

Gene Symbol

G0S2

UniProt

P27469 (Human)

Additional G0S2 Products

Product Documents for G0S2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for G0S2 Antibody

Manufactured by Genomic Antibody Technology™. GAT FAQs

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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