GAB1 Antibody (1A7) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-37742

Novus Biologicals, part of Bio-Techne
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NBP2-37742
NBP2-37742-0.025ml
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Key Product Details

Species Reactivity

Human

Applications

CyTOF-ready, ELISA, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 1A7

Format

BSA Free

Concentration

1 mg/ml

View all GAB1 Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of human GAB1 expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

76.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GAB1 Antibody (1A7) - BSA Free

Western Blot: GAB1 Antibody (1A7)BSA Free [NBP2-37742]

Western Blot: GAB1 Antibody (1A7)BSA Free [NBP2-37742]

Western Blot: GAB1 Antibody (1A7) [NBP2-37742] - Analysis using GAB1 mouse mAb against HEK293 (1) cell lysate.
Immunohistochemistry-Paraffin: GAB1 Antibody (1A7) - BSA Free [NBP2-37742]

Immunohistochemistry-Paraffin: GAB1 Antibody (1A7) - BSA Free [NBP2-37742]

Immunohistochemistry-Paraffin: GAB1 Antibody (1A7) [NBP2-37742] - Analysis of bladder cancer tissues using GAB1 mouse mAb with DAB staining.
Flow Cytometry: GAB1 Antibody (1A7) - BSA Free [NBP2-37742]

Flow Cytometry: GAB1 Antibody (1A7) - BSA Free [NBP2-37742]

Flow Cytometry: GAB1 Antibody (1A7) [NBP2-37742] - Analysis of Jurkat cells using GAB1 mouse mAb (green) and negative control (red).
View 3 more images

Applications for GAB1 Antibody (1A7) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Flow Cytometry

1:200 - 1:400

Immunohistochemistry

1:200 - 1:1000

Immunohistochemistry-Paraffin

1:200 - 1:1000

Western Blot

1:500 - 1:2000
Application Notes
This antibody is Cytof ready.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GAB1

Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter protein such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc and Gab 1 also participate in insulin signaling by linking the insulin receptor to Ras by forming complexes with GRB2 (another adapter protein) and Sos independently of IRS-1. Gab 1 is also thought to be involved in the EGF receptor signaling pathway.

Long Name

GRB2-associated Binding Protein 1

Alternate Names

GRB2-associated binder 1, GRB2-associated binding protein 1, GRB2-associated-binding protein 1, Growth factor receptor bound protein 2-associated protein 1

Gene Symbol

GAB1

Additional GAB1 Products

Product Documents for GAB1 Antibody (1A7) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GAB1 Antibody (1A7) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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