GAB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-81500

Novus Biologicals, part of Bio-Techne
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NBP1-81500
NBP1-81500-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GAB2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDST

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (88%), Rat (85%). Reactivity reported in scientific literature (PMID: 16524965)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GAB2 Antibody

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500]

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500]

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500] - Staining of human bone marrow shows moderate cytoplasmic positivity in hematopoietic cells.
Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500]

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500]

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500] - Analysis in human bone marrow and skeletal muscle tissues. Corresponding GAB2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500]

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500]

Immunohistochemistry-Paraffin: GAB2 Antibody [NBP1-81500] - Staining of human testis shows strong cytoplasmic and membranous positivity in cells in seminiferous ducts.
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Applications for GAB2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GAB2

Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).

Long Name

GRB2-associated Binding Protein 2

Alternate Names

p100

Gene Symbol

GAB2

Additional GAB2 Products

Product Documents for GAB2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GAB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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