GABA-A R beta 2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-198

Novus Biologicals, part of Bio-Techne
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NB300-198
NB300-198-0.025ml
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Cited:

Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Human (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GABA-A R beta 2 Antibodies »

Product Specifications

Immunogen

Fusion protein from the cytoplasmic loop of the beta 2 subunit. Accession # P63138

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 16807363).

Localization

Cell Membrane; multi pass membrane protein

Specificity

Specific for endogenous levels of the ~55 kDa beta 2-subunit of the GABAA receptor.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GABA-A R beta 2 Antibody

Western Blot: GABA-A R beta 2 Antibody [NB300-198]

Western Blot: GABA-A R beta 2 Antibody [NB300-198]

Western Blot: GABA-A R beta 2 Antibody [NB300-198] - 7 ug of rat cerebellum (Cb) showing specific immunolabeling of the ~55k beta2-subunit of the GABA-AR.

Applications for GABA-A R beta 2 Antibody

Application
Recommended Usage

Western Blot

1:1000
Application Notes
Immunoprecipitation 15 ug ** ** 68% of all GABA-A receptors in dodecylsulfate extracts of rat forebrains (150 ul)

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GABA-A R beta 2

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.

Long Name

gamma-Aminobutyric Acid Type A Receptor, beta-2 Polypeptide

Alternate Names

GABAAR beta 2, GABAARb2, GABRB2

Entrez Gene IDs

2561 (Human); 25451 (Rat)

Gene Symbol

GABRB2

UniProt

P63138 (Rat)

Additional GABA-A R beta 2 Products

Product Documents for GABA-A R beta 2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GABA-A R beta 2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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