GABA-A R delta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33421

Novus Biologicals, part of Bio-Techne
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NBP2-33421
NBP2-33421-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GABA-A R delta Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: KVKVSRPRAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSGGQGGIRARL

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (82%), Rat (82%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GABA-A R delta Antibody

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421]

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421]

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421] - Staining in human cerebral cortex and pancreas tissues using anti-GABRD antibody. Corresponding GABRD RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421]

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421]

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421] - Staining of human pancreas shows low expression as expected.
Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421]

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421]

Immunohistochemistry-Paraffin: GABA-A R delta Antibody [NBP2-33421] - Staining of human cerebral cortex shows high expression.

Applications for GABA-A R delta Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Use in Western blot reported in scientific literature (PMID 29020412).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GABA-A R delta

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a channel associated with the GABAA Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a g-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003). More recently there have been a number of studies demonstrating that the -subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).

Long Name

gamma-Aminobutyric Acid Type A Receptor, delta Polypeptide

Alternate Names

GABAAR delta, GABAARd, GABRD

Gene Symbol

GABRD

UniProt

O14764 (Human)

Additional GABA-A R delta Products

Product Documents for GABA-A R delta Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GABA-A R delta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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