GABA-AR alpha 1 Antibody (1F4) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-09048

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-09048-0.025mg
NBP3-09048-0.2mg
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, X-Ray Crystallography

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG2b Kappa Clone # 1F4

Format

Azide and BSA Free

Concentration

1 mg/ml

View all GABA-A R alpha 1 Antibodies »

Product Specifications

Immunogen

This antibody was raised against alpha 1 beta 2 gamma 2 GABA-A receptor.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for GABA-AR alpha 1 Antibody (1F4) - Azide and BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

X-Ray Crystallography

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
FSEC: High affinity and specificity of the 1F4 antibody to alpha 1 beta 2 gamma 2 GABA-A receptor was demonstrated using fluorescence-detection size exclusion chromatography with GFP-tagged receptor (shift in elution volume) (Zhu et al., 2018). Crystallography: Furthermore, this antibody was utilised in production and purification of the alpha 1 beta 2 gamma 2 GABA-A receptor (Zhu et al., 2018). Finally, Fab fragments derived from the antibody were used to facilitate crystallisation and improve stabilisation of the alpha 1 beta 2 gamma 2 GABA-A receptor (Zhu et al., 2018).

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GABA-A R alpha 1

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics.

Long Name

gamma-Aminobutyric Acid Type A Receptor, alpha-1 Polypeptide

Alternate Names

EJM, GABAAR alpha 1, GABAARa1, GABRA1

Gene Symbol

GABRA1

Additional GABA-A R alpha 1 Products

Product Documents for GABA-AR alpha 1 Antibody (1F4) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for GABA-AR alpha 1 Antibody (1F4) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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