GABA-AR alpha 3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14327

Novus Biologicals, part of Bio-Techne
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NBP3-14327
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bat (100%), Bovine (100%), Canine (100%), Equine (100%), Monkey (100%), Mouse (100%), Primate (100%), Rabbit (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all GABA A R alpha 3 Antibodies »

Product Specifications

Immunogen

Synthetic 15 amino acid peptide from N-Terminus of human GABA-AR alpha 3.

Epitope

N-Terminus

Reactivity Notes

Expected reactivity based on percent sequence identity: Opossum (87%)

Specificity

Human GABA-AR alpha 3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for GABA-AR alpha 3 Antibody

Immunohistochemistry-Paraffin: GABA-AR alpha 3 Antibody [NBP3-14327]

Immunohistochemistry-Paraffin: GABA-AR alpha 3 Antibody [NBP3-14327]

Immunohistochemistry-Paraffin: GABA-AR alpha 3 Antibody [NBP3-14327] - Immunohistochemistry of formalin-fixed, paraffin-embedded human brain, basal nucleus of Meynert after heat-induced antigen retrieval.

Applications for GABA-AR alpha 3 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: GABA A R alpha 3

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; P ltl et al., 2003).

Long Name

gamma-Aminobutyric Acid Type A Receptor, alpha-3 Polypeptide

Alternate Names

GABAARa3, GABRA3

Gene Symbol

GABRA3

Additional GABA A R alpha 3 Products

Product Documents for GABA-AR alpha 3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GABA-AR alpha 3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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