GABA-AR alpha 6 Antibody - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB300-150

Novus Biologicals, part of Bio-Techne
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NB300-150
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

Azide and BSA Free

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all GABA-A R alpha 6 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues specific to the alpha 6 subunit conjugated to KLH. Accession # P30191

Specificity

Specific for endogenous levels of the ~57 kDa alpha 6-subunit of the GABAA receptor.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage).

Scientific Data Images for GABA-AR alpha 6 Antibody - Azide and BSA Free

Western Blot: GABA-AR alpha 6 AntibodyAzide and BSA Free [NB300-150]

Western Blot: GABA-AR alpha 6 AntibodyAzide and BSA Free [NB300-150]

Western Blot: GABA-A R alpha 6 Antibody [NB300-150]

Applications for GABA-AR alpha 6 Antibody - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Western Blot

1:1000
Application Notes
In Western blot a band at approximately 57 kDa is seen. Use in Immunohistochemistry reported in scientific literature (PMID 18509076)

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Neat whole antisera

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GABA-A R alpha 6

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The alpha 6 subunit is expressed in cerebellar granule cells. Though it is concentrated at synapses, it is found on extrasynaptic membranes, as well.

Long Name

gamma-Aminobutyric Acid Type A Receptor, alpha-6 Polypeptide

Alternate Names

GABAAR alpha 6, GABAARa6, GABRA6

Entrez Gene IDs

2559 (Human); 14399 (Mouse); 29708 (Rat)

Gene Symbol

GABRA6

UniProt

P30191 (Rat)

Additional GABA-A R alpha 6 Products

Product Documents for GABA-AR alpha 6 Antibody - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GABA-AR alpha 6 Antibody - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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