GABA-B R1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-14033

Novus Biologicals, part of Bio-Techne
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NBP2-14033
NBP2-14033-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (97%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GABA-B R1 Antibodies »

Product Summary for GABA-B R1 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the amino acids: YKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GABA-B R1 Antibody

Immunohistochemistry-Paraffin: GABA-B R1 Antibody [NBP2-14033]

Immunohistochemistry-Paraffin: GABA-B R1 Antibody [NBP2-14033]

Immunohistochemistry-Paraffin: GABA-B R1 Antibody [NBP2-14033] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.

Applications for GABA-B R1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GABA-B R1

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Long Name

gamma-Aminobutyric Acid Type B Receptor Subunit 1

Alternate Names

GABABR1, GABBR1, Gb1, GPRC3A

Gene Symbol

GABBR1

Additional GABA-B R1 Products

Product Documents for GABA-B R1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GABA-B R1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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