GABA-B R2 Antibody (SR1039)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21952

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21952-100ul
NBP3-21952-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1039

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GABA-B R2 Antibodies »

Product Summary for GABA-B R2 Antibody (SR1039)

Immunogen

A synthesized peptide derived from human GABA-B R2 (Uniprot #: O75899)

Specificity

Detects endogenous levels of total GABA-B R2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

106 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GABA-B R2 Antibody (SR1039)

Western Blot: GABA-B R2 Antibody (SR1039) [NBP3-21952] -

Western Blot: GABA-B R2 Antibody (SR1039) [NBP3-21952] - Western blot analysis using NBP3-21952 in SH-SY5Y cell lysate.

Applications for GABA-B R2 Antibody (SR1039)

Application
Recommended Usage

Flow Cytometry

1:40

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GABA-B R2

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).

Long Name

gamma-Aminobutyric Acid Type B Receptor Subunit 2

Alternate Names

GABABR2, GABBR2, GPR51, GPRC3B

Gene Symbol

GABBR2

Additional GABA-B R2 Products

Product Documents for GABA-B R2 Antibody (SR1039)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GABA-B R2 Antibody (SR1039)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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