GABA-B R2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48516

Novus Biologicals, part of Bio-Techne
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NBP2-48516
NBP2-48516-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GABA-B R2 Antibodies »

Product Summary for GABA-B R2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: NPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GABA-B R2 Antibody

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516] - Staining of human liver shows low expression as expected.
Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody [NBP2-48516] - Staining of human cerebral cortex shows high expression.
View 1 more images

Applications for GABA-B R2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GABA-B R2

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).

Long Name

gamma-Aminobutyric Acid Type B Receptor Subunit 2

Alternate Names

GABABR2, GABBR2, GPR51, GPRC3B

Gene Symbol

GABBR2

Additional GABA-B R2 Products

Product Documents for GABA-B R2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GABA-B R2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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