GAD2/GAD65 Antibody (GAD2/2362) [PE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08704PE

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-07823

Alexa Fluor 350

NBP3-08704AF350

Alexa Fluor 405

NBP3-08704AF405

Alexa Fluor 488

NBP3-08704AF488

Alexa Fluor 532

NBP3-08704AF532

Alexa Fluor 594

NBP3-08704AF594

Alexa Fluor 647

NBP3-08704AF647

Alexa Fluor 700

NBP3-08704AF700

Alexa Fluor 750

NBP3-08704AF750

Allophycocyanin

NBP3-08704APC

Biotin

NBP3-08704B

CoraFluor 1

NBP3-08704CL1

DyLight 350

NBP3-08704UV

DyLight 405

NBP3-08704V

DyLight 488

NBP3-08704G

DyLight 550

NBP3-08704R

DyLight 594

NBP3-08704DL594

DyLight 650

NBP3-08704C

DyLight 680

NBP3-08704FR

DyLight 755

NBP3-08704IR

FITC

NBP3-08704F

HRP

NBP3-08704H

Janelia Fluor 525

NBP3-08704JF525

Janelia Fluor 549

NBP3-08704JF549

Janelia Fluor 585

NBP3-08704JF585

Janelia Fluor 635

NBP3-08704JF635

Janelia Fluor 646

NBP3-08704JF646

Janelia Fluor 669

NBP3-08704JF669

PerCP

NBP3-08704PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-08704

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin, Protein Array

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # GAD2/2362

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GAD2/GAD65 Antibodies »

Product Summary for GAD2/GAD65 Antibody (GAD2/2362) [PE]

Immunogen

Recombinant fragment of human GAD2/GAD65 protein (around aa 6-99) (exact sequence is proprietary) (Uniprot: Q05329)

Localization

Cytoplasmic

Marker

GABAergic Neuronal Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for GAD2/GAD65 Antibody (GAD2/2362) [PE]

Application

Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Protein Array

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: GAD2/GAD65

Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type 1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.

Long Name

Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa)

Alternate Names

GAD65

Gene Symbol

GAD2

Additional GAD2/GAD65 Products

Product Documents for GAD2/GAD65 Antibody (GAD2/2362) [PE]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for GAD2/GAD65 Antibody (GAD2/2362) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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