Galectin-2 Antibody (1H6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11293

Novus Biologicals, part of Bio-Techne
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NBP3-11293
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 1H6

Concentration

0.1 mg/ml

View all Galectin-2 Antibodies »

Product Summary for Galectin-2 Antibody (1H6)

Immunogen

Recombinant human galectin-2

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Galectin-2 Antibody (1H6)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunoassay

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
For Immunoassays, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Galectin-2

The monoclonal antibody 1H6 reacts with galectin-2. Galectins are beta-galactoside-binding lectins. They have a characteristic carbohydrate recognition domain (CRD) and are widely expressed in a wide range of organisms. Galectins are involved in the regulation of cell proliferation, inflammation, cell adhesion and cell death. Based on structural features, mammalian galectins have been classified as proto, chimera or tandem repeats. Galectin-2 is of the proto type. Proto types contain one CRD per subunit and are usually homodimers of non-covalently linked subunits. Although galectins lack a typical secretion signal peptide, they are present not only in the cytosol and the nucleus, but also in the extracellular space. During the infection process, galectins have diverse effects on cells involved in innate immune responses, including macrophages, dendritic cells, neutrophils and mast cells. For example many host-microorganism interactions have been shown to involve protein-carbohydrate recognition. Thereby facilitating the interaction with colonizing microorganism, or initiate innate and adaptive immune responses against the pathogen. Galectin-2 is structurally related to galectins-1 (43% sequence identity to gal-1), but is primarily expressed in the gastrointestinal tract and induces apoptosis in activated T-cells. Human and mouse gal-2 share ca 65% amino acid sequence similarity. The exact function of gal-2 remains unclear until now. Interaction studies showed binding of gal-2, present in macrophages and smooth muscle cells, to lymphotoxin-alpha and also alpha-and beta-tubulins, implicating involvement in regulation of cytokine secretion relevant for the pathogenesis of myocardial infarction. Furthermore, Gal-2 has proven growth-regulatory activity, is reactive with apoptotic cells, and has the potential to modulate cell adhesion.

Alternate Names

GAL2, Galectin2, LGALS2

Gene Symbol

LGALS2

Additional Galectin-2 Products

Product Documents for Galectin-2 Antibody (1H6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Galectin-2 Antibody (1H6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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