gamma-Synuclein Antibody (4A0F4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16144

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16144-100ul
NBP3-16144-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 4A0F4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all gamma-Synuclein Antibodies »

Product Summary for gamma-Synuclein Antibody (4A0F4)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 48-127 of human gamma-Synuclein (O76070). VVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for gamma-Synuclein Antibody (4A0F4)

Western Blot: gamma-Synuclein Antibody (4A0F4) [NBP3-16144]

Western Blot: gamma-Synuclein Antibody (4A0F4) [NBP3-16144]

Western Blot: gamma-Synuclein Antibody (4A0F4) [NBP3-16144] - Western blot analysis of extracts of various cell lines, using gamma-Synuclein Rabbit mAb (NBP3-16144) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.
Immunohistochemistry-Paraffin: gamma-Synuclein Antibody (4A0F4) [NBP3-16144]

Immunohistochemistry-Paraffin: gamma-Synuclein Antibody (4A0F4) [NBP3-16144]

Immunohistochemistry-Paraffin: gamma-Synuclein Antibody (4A0F4) [NBP3-16144] - Immunohistochemistry of paraffin-embedded rat brain using gamma-Synuclein Rabbit mAb (NBP3-16144) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Applications for gamma-Synuclein Antibody (4A0F4)

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: gamma-Synuclein

Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. May be a centrosome-associated protein. Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. Belongs to the synuclein family.

Alternate Names

BCSG1, PRSN, SNCG, Synoretin, Synuclein-gamma

Gene Symbol

SNCG

Additional gamma-Synuclein Products

Product Documents for gamma-Synuclein Antibody (4A0F4)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for gamma-Synuclein Antibody (4A0F4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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