GAT3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-91920

Novus Biologicals, part of Bio-Techne
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NBP1-91920
NBP1-91920-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GAT3 Antibodies »

Product Summary for GAT3 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKETHF

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (85%), Rat (87%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GAT3 Antibody

Western Blot: GAT3 Antibody [NBP1-91920]

Western Blot: GAT3 Antibody [NBP1-91920]

Western Blot: GAT3 Antibody [NBP1-91920] - Analysis in human cerebral cortex tissue.
Immunohistochemistry-Paraffin: GAT3 Antibody [NBP1-91920]

Immunohistochemistry-Paraffin: GAT3 Antibody [NBP1-91920]

Immunohistochemistry-Paraffin: GAT3 Antibody [NBP1-91920] - Staining of human Liver shows no positivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: GAT3 Antibody [NBP1-91920]

Immunohistochemistry-Paraffin: GAT3 Antibody [NBP1-91920]

Immunohistochemistry-Paraffin: GAT3 Antibody [NBP1-91920] - Staining of human Cerebellum shows strong positivity in processes in cells in molecular layer.
View 2 more images

Applications for GAT3 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GAT3

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-3 has been found to be localized to astrocytes within the cerebral cortex indicating that this transporter mediates GABA uptake into glial cells (Minelli et al., 1996).

Long Name

Sodium- and chloride-dependent GABA transporter 3

Alternate Names

GABT3, GAT-3, SLC6A11

Gene Symbol

SLC6A11

Additional GAT3 Products

Product Documents for GAT3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GAT3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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