GCAP3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-91930

Novus Biologicals, part of Bio-Techne
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NBP1-91930
NBP1-91930-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GCAP3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFIDFLEFIAAVNLIMQE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GCAP3 Antibody

Immunocytochemistry/ Immunofluorescence: GCAP3 Antibody [NBP1-91930]

Immunocytochemistry/ Immunofluorescence: GCAP3 Antibody [NBP1-91930]

Immunocytochemistry/Immunofluorescence: GCAP3 Antibody [NBP1-91930] - Staining of human cell line RPTEC TERT1 shows localization to focal adhesion sites.
Immunohistochemistry: GCAP3 Antibody [NBP1-91930]

Immunohistochemistry: GCAP3 Antibody [NBP1-91930]

Immunohistochemistry: GCAP3 Antibody [NBP1-91930] - Staining of human colon shows moderate membranous and cytoplasmic positivity in glandular cells.

Applications for GCAP3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GCAP3

GCAP3, also known as GUCA1C or Guanylyl cyclase-activating protein 3, has a 209 amino acid isoform that is 24 kDa and a short 196 amino acid isoform that is approx. 22 kDa; commonly found in retina; in conditions of low free calcium ions concentration stimulates guanylyl cyclase 1 (GC1) and GC2 and when the concentration is elevated inhibits guanylyl cyclases, which is very important for the recuperation of the dark state of rod photoreceptors following light exposure. Disease research has linked this protein with cone dystrophy, neuronitis, and retinitis. This protein has shown interactions with GUCA1A, GUCA1B, GUCY2D, GUCY2F, and CNGA3 proteins in the pathways such as the visual cycle in retinal rods, olfactory transduction, and phototransduction pathways.

Alternate Names

GCAP3GCAP 3, guanylate cyclase activator 1CMGC120159, guanylyl cyclase-activating protein 3, MGC120158

Gene Symbol

GUCA1C

Additional GCAP3 Products

Product Documents for GCAP3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GCAP3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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