GITR/TNFRSF18 Antibody (DTA-1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26661

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2b Lambda Clone # DTA-1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GITR/TNFRSF18 Antibodies »

Product Specifications

Immunogen

Mouse CD25+ CD4+ T cell line NP_683700

Clonality

Monoclonal

Host

Rat

Isotype

IgG2b Lambda

Scientific Data Images for GITR/TNFRSF18 Antibody (DTA-1)

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661] - Analysis using the PE conjugate of NBP2-26661. Staining of GITR in mouse splenocytes using 0.2 ug/10^6 cells of this antibody; red represents anti-GITR antibody.
Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661] - Analysis of GITR in C57 mouse splenocytes using 0.1 ug of this antibody. Shaded histogram represents cells without antibody; green represents isotype control; red represents anti-GITR antibody.
Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661]

Flow Cytometry: GITR/TNFRSF18 Antibody (DTA-1) [NBP2-26661] - Analysis using the Allophycocyanin conjugate of NBP2-26661. Staining of GITR in mouse splenocytes using 0.2 ug of this antibody. Green represents isotype control; red represents anti-GITR antibody.
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Applications for GITR/TNFRSF18 Antibody (DTA-1)

Application
Recommended Usage

Flow Cytometry

1:10 - 1:1000

Immunoprecipitation

1:10 - 1:500

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, 0.05% BSA.

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GITR/TNFRSF18

GITR or TNFRSF18 is a 241 amino acid novel member of the tumor necrosis factor receptor superfamily and a receptor for TNFSF18. It has three extracytoplasmic cysteine-rich pseudorepeats, a small cytoplasmic tail and a DEATH domain. It is an essential regulator of immune responses to self tissues and pathogens and plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. It is known to be involved in regulation of CD3-driven T-cell activation and programmed cell death and also in interactions between activated T-lymphocytes and endothelial cells. In mammalian cells it mediates NF-kappa-B activation via TRAF2 and modulates T lymphocyte survival in peripheral tissues. It is mostly expressed in lymph node, peripheral blood leukocytes and weakly expressed in spleen. GITR and its ligand are also known to be involved in atopic dermatitis.

Long Name

Glucocorticoid Induced TNF Receptor Family Related Gene

Alternate Names

AITR, CD357, TNFRSF18

Gene Symbol

TNFRSF18

UniProt

Q9Y5U5

Additional GITR/TNFRSF18 Products

Product Documents for GITR/TNFRSF18 Antibody (DTA-1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GITR/TNFRSF18 Antibody (DTA-1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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