GKAP/DLGAP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-24868

Novus Biologicals, part of Bio-Techne
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NBP3-24868
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GKAP/DLGAP1 Antibodies »

Product Summary for GKAP/DLGAP1 Antibody

Immunogen

This antibody has been engineered to specifically recognize the recombinant protein GKAP/DLGAP1 using the following amino acid sequence: MKALTAAIEAANAQIHGPASQHMGNNTATVTTTTTIATVTTEDRKKDHFKKNRCLSIGIQVDDAEEPDKTGENKAPSKFQS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GKAP/DLGAP1 Antibody

GKAP/DLGAP1 Antibody Immunocytochemistry/Immunofluorescence: GKAP/DLGAP1 Antibody [NBP3-24868]

Immunocytochemistry/Immunofluorescence: GKAP/DLGAP1 Antibody [NBP3-24868]

Staining of human cell line U2OS shows localization to cytosol.

Applications for GKAP/DLGAP1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 µg/ml
Application Notes
For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GKAP/DLGAP1

Members of the postsynaptic density-95 (PSD-95)/SAP90 family of membraneassociated guanylate kinase (MAGUK) proteins function as multimodular scaffolds that organize protein-signaling complexes at neuronal synapses. PSD-95/SAP90 binds guanylate kinase-associated protein (GKAP), also designated GK domain-binding protein, DAP-1-alpha, DAP-1-beta, PSD-95 binding protein, PSD-95/SAP90 associated protein, or SAPAP1, through the guanylate kinase domain. SAPAP1 is expressed widely in neurons of the cortex and hippocampus and in the Purkinje and granule cells of the cerebellum. N-terminal splice variants of SAPAP1 are expressed as 95 and 130 kDa proteins. SAPAP1 is localized specifically in the PSD of glutamatergic synapses, consistent with its direct interaction with PSD-95 family proteins.

Long Name

Guanylate Kinase-associated Protein

Alternate Names

DAP1, DLGAP1, SAPAP1

Gene Symbol

DLGAP1

Additional GKAP/DLGAP1 Products

Product Documents for GKAP/DLGAP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GKAP/DLGAP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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