GluR5/GRIK1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-68165

Novus Biologicals, part of Bio-Techne
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NB100-68165
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all GluR5/GRIK1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence QCKQTHPTNSTS corresponding to internal region (near C-Terminus) according to NP_783300.1.

Epitope

QCKQTHPTNSTS

Specificity

This antibody is expected to recognise both reported isoforms according to NP_000821.1 and NP_783300.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GluR5/GRIK1 Antibody

Western Blot: GluR5/GRIK1 Antibody [NB100-68165]

Western Blot: GluR5/GRIK1 Antibody [NB100-68165]

Western Blot: GluR5/GRIK1 Antibody [NB100-68165] - (1ug/ml) staining of Human Brain (Cerebellum) 35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for GluR5/GRIK1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 150 kDa band observed in human brain is reported in scientific literature (PMID: 15483117). An additional very strong band of unknown identity was also consistently observed at 60 kDa. This band was successfully blocked by incubation with the immunizing peptide.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GluR5/GRIK1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.

Long Name

Glutamate Receptor 5

Alternate Names

EAA3, EEA3, GluK1, GRIK1

Entrez Gene IDs

2897 (Human); 14805 (Mouse); 29559 (Rat)

Gene Symbol

GRIK1

UniProt

NP_000821.1 (Human)

Additional GluR5/GRIK1 Products

Product Documents for GluR5/GRIK1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GluR5/GRIK1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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