Glutathione Reductase Antibody (6B4)

Novus Biologicals, part of Bio-Techne | Catalog # H00002936-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 6B4

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Glutathione Reductase Antibodies »

Product Specifications

Immunogen

GSR (NP_000628, 413 a.a. ~ 522 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Localization

Cytoplasmic

Specificity

GSR - glutathione reductase

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Glutathione Reductase Antibody (6B4)

Western Blot: Glutathione Reductase Antibody (6B4) [H00002936-M01]

Western Blot: Glutathione Reductase Antibody (6B4) [H00002936-M01]

Western Blot: Glutathione Reductase Antibody (6B4) [H00002936-M01] - Analysis of GSR expression in transfected 293T cell line by GSR monoclonal antibody (M01), clone 6B4.Lane 1: GSR transfected lysate(56.3 KDa).Lane 2: Non-transfected lysate.
Immunohistochemistry-Paraffin: Glutathione Reductase Antibody (6B4) [H00002936-M01]

Immunohistochemistry-Paraffin: Glutathione Reductase Antibody (6B4) [H00002936-M01]

Immunohistochemistry-Paraffin: Glutathione Reductase Antibody (6B4) [H00002936-M01] - Analysis of monoclonal antibody to GSR on formalin-fixed paraffin-embedded human salivary gland. Antibody concentration 6 ug/ml.
Western Blot: Glutathione Reductase Antibody (6B4) [H00002936-M01]

Western Blot: Glutathione Reductase Antibody (6B4) [H00002936-M01]

Western Blot: Glutathione Reductase Antibody (6B4) [H00002936-M01] - Analysis of GSR over-expressed 293 cell line, cotransfected with GSR Validated Chimera RNAi ( Cat # H00002936-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with GSR monoclonal antibody (M01), clone 6B4 (Cat # H00002936-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
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Applications for Glutathione Reductase Antibody (6B4)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P, RNAi Validation and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Glutathione Reductase

Glutathione reductase (GR) is a member of pyridine nucleotide-disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione(GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+ ->2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

Alternate Names

GLUR, GRase, GRD1, GSR, HEL-752

Entrez Gene IDs

2936 (Human)

Gene Symbol

GSR

OMIM

138300 (Human)

UniProt

NP_000628 (Human)

Additional Glutathione Reductase Products

Product Documents for Glutathione Reductase Antibody (6B4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Glutathione Reductase Antibody (6B4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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