Glutathione S-Transferase mu 1/GSTM1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-932

Novus Biologicals, part of Bio-Techne
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NB300-932
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Peptide ELISA, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Glutathione S-Transferase mu 1/GSTM1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence CVFSKMAVWGNK corresponding to C-Terminus according to NP_000552.2, NP_666533.1, NP_000839.1.

Specificity

This antibody is expected to recognise both reported variants of human GSTM1 protein (NP_000552.2; NP_666533.1) and wil also recognise human GSTM2 protein (NP_000839.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Glutathione S-Transferase mu 1/GSTM1 Antibody

Western Blot: Glutathione S-Transferase mu 1/GSTM1 Antibody [NB300-932]

Western Blot: Glutathione S-Transferase mu 1/GSTM1 Antibody [NB300-932]

Western Blot: GSTM1 Antibody [NB300-932] - Western blot analysis of GSTM1 / GSTM2 in Human Lung lysate using NB300-932 at 0.3ug/ml.
Western Blot: Glutathione S-Transferase mu 1/GSTM1 Antibody [NB300-932]

Western Blot: Glutathione S-Transferase mu 1/GSTM1 Antibody [NB300-932]

Western Blot: GSTM1 Antibody [NB300-932] - (0.3ug/ml) staining of Human Lung lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Glutathione S-Transferase mu 1/GSTM1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:1000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 26 kDa band observed in human liver and human lung lysates (calculated MW of 25.7 kDa band according to NP_000552.2, and NP_000839.1).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Glutathione S-Transferase mu 1/GSTM1

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Alternate Names

Glutathione STransferase mu 1, GST1, GSTM1, GTH4, GTM1

Entrez Gene IDs

2946 (Human)

Gene Symbol

GSTM1

UniProt

NP_000552 (Human)

Additional Glutathione S-Transferase mu 1/GSTM1 Products

Product Documents for Glutathione S-Transferase mu 1/GSTM1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Glutathione S-Transferase mu 1/GSTM1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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