GNB3 Antibody (M1-1-1D5)

Novus Biologicals, part of Bio-Techne | Catalog # H00002784-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # M1-1-1D5

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GNB3 Antibodies »

Product Specifications

Immunogen

GNB3 (AAH02454, 1 a.a. ~ 340 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MGEMEQLRQEAEQLKKQIADARKACAGVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICSITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN

Specificity

GNB3 - guanine nucleotide binding protein (G protein), beta polypeptide 3

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for GNB3 Antibody (M1-1-1D5)

Western Blot: GNB3 Antibody (M1-1-1D5) [H00002784-M01]

Western Blot: GNB3 Antibody (M1-1-1D5) [H00002784-M01]

Western Blot: GNB3 Antibody (M1-1-1D5) [H00002784-M01] - GNB3 monoclonal antibody (M01), clone M1-1-1D5 Analysis of GNB3 expression in HepG2.
Immunocytochemistry/ Immunofluorescence: GNB3 Antibody (M1-1-1D5) [H00002784-M01]

Immunocytochemistry/ Immunofluorescence: GNB3 Antibody (M1-1-1D5) [H00002784-M01]

Immunocytochemistry/Immunofluorescence: GNB3 Antibody (M1-1-1D5) [H00002784-M01] - Analysis of monoclonal antibody to GNB3 on HepG2 cell. Antibody concentration 10 ug/ml.

Applications for GNB3 Antibody (M1-1-1D5)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate for WB. It has been used for IF and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: GNB3

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.

Alternate Names

G protein, beta-3 subunit, GTP-binding regulatory protein beta-3 chain, guanine nucleotide binding protein (G protein), beta polypeptide 3, guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3, hypertension associated protein, Transducin beta chain 3

Entrez Gene IDs

2784 (Human)

Gene Symbol

GNB3

OMIM

139130 (Human)

UniProt

AAH02454 (Human)

Additional GNB3 Products

Product Documents for GNB3 Antibody (M1-1-1D5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GNB3 Antibody (M1-1-1D5)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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