GnRH Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-506

Novus Biologicals, part of Bio-Techne
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NB300-506
NB300-506-0.025ml
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Key Product Details

Species Reactivity

Validated:

Mouse, Amphibian

Cited:

Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all GnRH Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues pyroE(22) H W S Y G L R P G-NH2(32) of mouse GnRH.

Reactivity Notes

Mouse reactivity reported in scientific literatures (PMID: 21303944 and 25958044).

Specificity

GnRH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GnRH Antibody

Immunohistochemistry-Paraffin: GnRH Antibody [NB300-506]

Immunohistochemistry-Paraffin: GnRH Antibody [NB300-506]

Immunohistochemistry-Paraffin: GnRH Antibody [NB300-506] - Immunolocalization of GnRH in mouse embryo brain.
Immunohistochemistry-Paraffin: GnRH Antibody [NB300-506]

Immunohistochemistry-Paraffin: GnRH Antibody [NB300-506]

Immunohistochemistry-Paraffin: GnRH Antibody [NB300-506] - Analysis of Hyla cinerea (green treefrog) forebrain using GnRH Polyclonal Antibody. Tissues were blocked in 10% normal goat serum in 0.1M PBS and then stained. Staining was developed with DAB substrate for 10 minutes. Data courtesy of Innovators Program.

Applications for GnRH Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10 - 1:500

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:1000
Application Notes
May be useful in IF and IHC-P. IF: Staining of GnRH in mouse embryo brain tissue results in staining of neurons in the rostral forebrain. IHC: 4% paraformaldehyde is recommended as a fixative.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GnRH

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.

Alternate Names

GNRH, GnRH-associated peptide 1, gonadotropin-releasing hormone 1 (leutinizing-releasing hormone), gonadotropin-releasing hormone 1 (luteinizing-releasing hormone), GRH, LHRH, LNRH, luliberin I, Progonadoliberin I, progonadoliberin-1, prolactin release-inhibiting factor

Entrez Gene IDs

2796 (Human); 14715 (Mouse)

Gene Symbol

Gnrh1

Additional GnRH Products

Product Documents for GnRH Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GnRH Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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