GnRHR Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55552

Novus Biologicals, part of Bio-Techne
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NBP2-55552
NBP2-55552-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GnRHR Antibodies »

Product Summary for GnRHR Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIR

Reactivity Notes

Mouse 82%, Rat 87%

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GnRHR Antibody

Immunohistochemistry-Paraffin: GnRHR Antibody [NBP2-55552]

Immunohistochemistry-Paraffin: GnRHR Antibody [NBP2-55552]

Immunohistochemistry-Paraffin: GnRHR Antibody [NBP2-55552] - Staining of human pituitary gland shows moderate cytoplasmic positivity in cells in anterior lobe.

Applications for GnRHR Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GnRHR

GnRHR encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Long Name

Gonadotropin-releasing Hormone Receptor

Alternate Names

GNRHR1, GRHR, HH7, LHRHR, LRHR, Luliberin

Gene Symbol

GNRHR

Additional GnRHR Products

Product Documents for GnRHR Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GnRHR Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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