GPR17 Antibody (CL10474)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-07993

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL10474

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GPR17 Antibodies »

Product Summary for GPR17 Antibody (CL10474)

Immunogen

This antibody was developed against a synthetic peptide corresponding to amino acids: KRLKGPPPSFEGKTNESSLS

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for GPR17 Antibody (CL10474)

Immunohistochemistry-Paraffin: GPR17 Antibody (CL10474) [NBP3-07993]

Immunohistochemistry-Paraffin: GPR17 Antibody (CL10474) [NBP3-07993]

Immunohistochemistry-Paraffin: GPR17 Antibody (CL10474) [NBP3-07993] - Analysis in human cerebral cortex and kidney tissues using NBP3-07993 antibody. Corresponding GPR17 RNA-seq data are presented for the same tissues.
Western Blot: GPR17 Antibody (CL10474) [NBP3-07993]

Western Blot: GPR17 Antibody (CL10474) [NBP3-07993]

Western Blot: GPR17 Antibody (CL10474) [NBP3-07993] - Analysis in human cell line U-251 MG.
Immunohistochemistry-Paraffin: GPR17 Antibody (CL10474) [NBP3-07993]

Immunohistochemistry-Paraffin: GPR17 Antibody (CL10474) [NBP3-07993]

Immunohistochemistry-Paraffin: GPR17 Antibody (CL10474) [NBP3-07993] - Staining of human prostate shows no positivity in glandular cells as expected.
View 3 more images

Applications for GPR17 Antibody (CL10474)

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, containing 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GPR17

GPR17, a former orphan G-coupled protein is specifically activated by P2Y and CysLT endogenous ligands, leading to both adenylyl cyclase inhibition and intracellular calcium increases. In both rats and humans GPR17 expressed in the organs which suffer ischemic damage, like the brain, heart and kidneys. Studies by Ciana, et. al. have shown that inhibition of GPR17 reduces ischemic damage in a rat focal ischemia model. These results suggest GPR17 is the common molecular target mediating brain damage by nucleotides and CysLTs.

Long Name

G Protein-coupled Receptor 17

Alternate Names

P2Y-like Receptor, R12, UDP/CysLT Receptor

Gene Symbol

GPR17

Additional GPR17 Products

Product Documents for GPR17 Antibody (CL10474)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GPR17 Antibody (CL10474)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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