GRB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55209

Novus Biologicals, part of Bio-Techne
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NBP2-55209
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GRB2 Antibodies »

Product Summary for GRB2 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GRB2 Antibody

Western Blot: GRB2 Antibody [NBP2-55209]

Western Blot: GRB2 Antibody [NBP2-55209]

Western Blot: GRB2 Antibody [NBP2-55209] - Analysis using Anti-GRB2 antibody NBP2-55209 (A) shows similar pattern to independent antibody NBP2-55208 (B).
Immunocytochemistry/ Immunofluorescence: GRB2 Antibody [NBP2-55209]

Immunocytochemistry/ Immunofluorescence: GRB2 Antibody [NBP2-55209]

Immunocytochemistry/Immunofluorescence: GRB2 Antibody [NBP2-55209] - Staining of human cell line PC-3 shows localization to nucleoplasm.

Applications for GRB2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Western Blot

0.04-0.4 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GRB2

The growth factor bound protein 2 (GRB2) is a 25 kDa cytosolic protein that contains one src homology (SH2) domain and two SH3 domains (1). GRB2 associates with Tyrosine phosphorylated EGFRs and PDGFRs via its SH2 domain. GRB2 also plays a crucial role in two separate insulin pathways leading from the insulin receptor to the Ras protein thus affecting mitogenic signaling (2). Additionally GBR2, a bifunctional adaptor protein, recruits Sos for Ras activation and subsequent signal transmission (3).

Long Name

Growth Factor Receptor-Bound Protein 2

Alternate Names

ASH, EGFRBP-GRB2, Grb3-3

Gene Symbol

GRB2

Additional GRB2 Products

Product Documents for GRB2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GRB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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