Gremlin 1 Antibody (4C2)

Novus Biologicals, part of Bio-Techne | Catalog # H00026585-M04

Novus Biologicals, part of Bio-Techne
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H00026585-M04
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 4C2

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Gremlin Antibodies »

Product Specifications

Immunogen

GREM1 (NP_037504, 75 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. ESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD

Reactivity Notes

Other species not tested.

Specificity

GREM1 - gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Scientific Data Images for Gremlin 1 Antibody (4C2)

ELISA: Gremlin 1 Antibody (4C2) [H00026585-M04]

ELISA: Gremlin 1 Antibody (4C2) [H00026585-M04]

ELISA: Gremlin 1 Antibody (4C2) [H00026585-M04] - Detection limit for recombinant GST tagged GREM1 is approximately 3ng/ml as a capture antibody.

Applications for Gremlin 1 Antibody (4C2)

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

1:500
Application Notes
Antibody reactive against recombinant protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Gremlin

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.

Alternate Names

DAND2, DRM, GREM1

Entrez Gene IDs

26585 (Human)

Gene Symbol

GREM1

OMIM

603054 (Human)

UniProt

NP_037504 (Human)

Additional Gremlin Products

Product Documents for Gremlin 1 Antibody (4C2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Gremlin 1 Antibody (4C2)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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