GULP1/CED-6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1042

Novus Biologicals, part of Bio-Techne
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NB100-1042
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all GULP1/CED-6 Antibodies »

Product Specifications

Immunogen

Peptide with sequence EGTVFCLDPLDSRC corresponding to C-Terminus according to NP_057399.1.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GULP1/CED-6 Antibody

Western Blot: GULP1/CED-6 Antibody [NB100-1042]

Western Blot: GULP1/CED-6 Antibody [NB100-1042]

Western Blot: GULP1/CED-6 Antibody [NB100-1042] - Analysis of GULP1 in Human Placenta lysate (RIPA buffer, 30ug total protein per lane) using NB100-1042 at 0.2ug/ml. Primary incubated for 1 hour. Detected using chemiluminescence.
Immunohistochemistry-Paraffin: GULP1/CED-6 Antibody [NB100-1042]

Immunohistochemistry-Paraffin: GULP1/CED-6 Antibody [NB100-1042]

Immunohistochemistry-Paraffin: GULP1/CED-6 Antibody [NB100-1042] - Analysis of GULP1 in paraffin embedded Human Kidney using NB100-1042 at 5ug/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for GULP1/CED-6 Antibody

Application
Recommended Usage

Immunohistochemistry

5 - 10 ug/ml

Immunohistochemistry-Paraffin

5 - 10 ug/ml

Peptide ELISA

Detection limit 1:64000

Western Blot

0.2 - 0.6 ug/ml
Application Notes
WB: Approx. 35 kDa band observed in human placenta lysates (calculated MW of 34.5 kDa band according to NP_057399.1). An additional band of unknown identity was also consistently observed at approx.46 kDa. This band was successfully blocked by incubation with the immunizing peptide. IHC-P: Human kidney shows staining of cytoplasm, stronger in a selection of epithelial cells of distal convoluted tubules.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GULP1/CED-6

The prompt clearance of cells undergoing apoptosis is critical during embryonic development, normal tissue turnover, as well as inflammation and autoimmunity. CED6 and its human homologue gulp, encode an adapter protein, whose function in engulfment. The upstream and downstream components of CED6 mediated signaling are not known. Recently, CED1 has been shown to encode a transmembrane protein on phagocytic cells, with two functional sequence motifs in its cytoplasmic tail that are important for engulfment.

Alternate Names

CED6

Entrez Gene IDs

51454 (Human); 70676 (Mouse)

Gene Symbol

GULP1

UniProt

Q9UBP9 (Human)

Additional GULP1/CED-6 Products

Product Documents for GULP1/CED-6 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GULP1/CED-6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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