HAAO Antibody (4D1)

Novus Biologicals, part of Bio-Techne | Catalog # H00023498-M05

Novus Biologicals, part of Bio-Techne
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H00023498-M05
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Key Product Details

Species Reactivity

Human, Bacteria

Applications

ELISA, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 4D1

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HAAO Antibodies »

Product Specifications

Immunogen

HAAO (AAH29510.1, 97 a.a. ~ 196 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. ANTVGLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQA

Specificity

HAAO - 3-hydroxyanthranilate 3,4-dioxygenase (4D1)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for HAAO Antibody (4D1)

Sandwich ELISA: HAAO Antibody (4D1) [H00023498-M05] - Detection limit for recombinant GST tagged HAAO is 0.1 ng/ml as a capture antibody.

Applications for HAAO Antibody (4D1)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: HAAO

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq]

Alternate Names

3-HAO, 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilic acid dioxygenase, EC 1.13.11.6,3-hydroxyanthranilate oxygenase, HAD, HAO

Entrez Gene IDs

23498 (Human)

Gene Symbol

HAAO

UniProt

AAH29510 (Human)

Additional HAAO Products

Product Documents for HAAO Antibody (4D1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HAAO Antibody (4D1)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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