HAX-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-54800

Novus Biologicals, part of Bio-Techne
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NBP1-54800
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all HAX-1 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to HAX1(HCLS1 associated protein X-1) The peptide sequence was selected from the middle region of HAX1. Peptide sequence LPGPESETPGERLREGQTLRDSMLKYPDSHQPRIFGGVLESDARSESPQP. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

31 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for HAX-1 Antibody

Western Blot: HAX-1 Antibody [NBP1-54800]

Western Blot: HAX-1 Antibody [NBP1-54800]

Western Blot: HAX-1 Antibody [NBP1-54800] - COLO205 cells lysate, concentration 0.2-1 ug/ml.
Immunohistochemistry: HAX-1 Antibody [NBP1-54800]

Immunohistochemistry: HAX-1 Antibody [NBP1-54800]

Immunohistochemistry: HAX-1 Antibody [NBP1-54800] - Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue Observed Staining: Cytoplasmic Primary Antibody Concentration: 1:100 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec

Applications for HAX-1 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HAX-1

HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

Long Name

HCLS1 associated protein X-1

Alternate Names

HAX1, HCLSBP1, HS1BP1, SCN3

Gene Symbol

HAX1

UniProt

O00165 (Human)

Additional HAX-1 Products

Product Documents for HAX-1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HAX-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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