HCN1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-20250

Novus Biologicals, part of Bio-Techne
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NBP1-20250
NBP1-20250-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse, Rat

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all HCN1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide from cytoplasmic region of human HCN1 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including mouse and rat.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for HCN1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:300-1:2000

Western Blot

1:300-1:2000
Application Notes
Immunohistochemistry and Western Blot. Although not tested this antibody may be useful in Immunohistochemistry-Paraffin/Frozen. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID:31923455).

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HCN1

FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli.; SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN2. Interacts with KCNE2.; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.; TISSUE SPECIFICITY: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.; DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Long Name

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Alternate Names

BCNG-1, BCNG1, EIEE24, GEFSP10, HAC-2

Entrez Gene IDs

348980 (Human); 15165 (Mouse); 84390 (Rat)

Gene Symbol

HCN1

UniProt

O60741 (Human)

Additional HCN1 Products

Product Documents for HCN1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HCN1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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