HDAC6 Antibody [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-78981V

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Negative), Western Blot (Negative)

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Histone Deacetylase 6/HDAC6 Antibodies »

Product Summary for HDAC6 Antibody [DyLight 405]

Immunogen

A synthetic peptide made to a C-terminal portion of the human HDAC6 protein (between residues 1175-1215). [UniProt Q9UBN7]

Localization

Nucleus. Cytoplasm. Note: It is cytoplasmic when associated with microtubules.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for HDAC6 Antibody [DyLight 405]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Histone Deacetylase 6/HDAC6

Histone deacetylase 6 (HDAC-6, HD6, and JM21) is a class II histone deacetylase/AcuC/AphA family member. HDAC-6 primarily functions to alter chromosome structure, regulate transcription factor access to DNA, and deacetylate the lysine residues on the N-terminal region of histones. The deacetylase activity, in turn, has a role in the degradation of misfolded proteins by autophagy (PMID: 21235576). The HDAC-6 protein contains two catalytic domains that function independently of each other and plays an important role in cell motility (microtubule dependent) by the deacetylation of tubulin. Research involving HDAC-6 includes cancer development and progression, Parkinson's disease, and epigenetics (PMID: 21455583, 21235576).

Long Name

Histone Deacetylase 6

Alternate Names

CPBHM, FLJ16239, HD6, HDAC6, JM21, PPP1R90

Gene Symbol

HDAC6

Additional Histone Deacetylase 6/HDAC6 Products

Product Documents for HDAC6 Antibody [DyLight 405]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HDAC6 Antibody [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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