HES6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-57558

Novus Biologicals, part of Bio-Techne
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NBP2-57558
NBP2-57558-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HES6 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: PIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HES6 Antibody

Immunocytochemistry/ Immunofluorescence: HES6 Antibody [NBP2-57558]

Immunocytochemistry/ Immunofluorescence: HES6 Antibody [NBP2-57558]

Immunocytochemistry/Immunofluorescence: HES6 Antibody [NBP2-57558] - Staining of human cell line U-2 OS shows localization to nucleoli, nuclear bodies & cytosol. Antibody staining is shown in green.

Applications for HES6 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HES6

HES6 is a transcription cofactor that itself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumor and cancer cell lines, although these have not yet been elucidated fully.

Alternate Names

BHLHB41, bHLHb41Class B basic helix-loop-helix protein 41, bHLHc23, C-HAIRY1, Hairy and enhancer of split 6, hairy and enhancer of split 6 (Drosophila), HES-6, transcription cofactor HES-6

Gene Symbol

HES6

Additional HES6 Products

Product Documents for HES6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HES6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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