HEXB Antibody (HEXB/7762)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-23584

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2 kappa Clone # HEXB/7762

Concentration

0.2 mg/ml

View all Hexosaminidase B/HEXB Antibodies »

Product Summary for HEXB Antibody (HEXB/7762)

Immunogen

Recombinant fragment human HEXB protein (exact sequence is proprietary)

Localization

Lysosome.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2 kappa

Description

Store at 2 to 8C. Non-hazardous. No MSDS required.

Scientific Data Images for HEXB Antibody (HEXB/7762)

HEXB Antibody (HEXB/7762)

Immunohistochemistry-Paraffin: HEXB Antibody (HEXB/7762) [NBP3-23584] -

Formalin-fixed, paraffin-embedded human placenta stained with HEXB antibody (HEXB/7762). Inset: PBS instead of primary antibody; secondary only negative control.

Applications for HEXB Antibody (HEXB/7762)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml
Application Notes
Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Hexosaminidase B/HEXB

HEXB, also known as Beta-hexosaminidase subunit beta, is a 556 amino acid that is 63 kDa, lysosome located, composed of two subunits, alpha and beta, which are encoded by separate gene, and in control of the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. Current research is being performed on several diseases and disorders including gangliosidosis, sandhoff disease, infantile, juvenile, and adult forms, tay-sachs disease, neuronitis, lysosomal storage disease, motor neuron disease, cervical cancer, mucopolysaccharidosis, cervicitis, neurodegenerative disease, recurrent respiratory papillomatosis, hairy cell leukemia, macrocephaly, autonomic dysfunction, cholesteatoma, type 2 diabetes mellitus, rheumatoid arthritis, and diarrhea. The protein has been linked to pathways such as glycan degradation, amino sugar and nucleotide sugar metabolism, glycosaminoglycan degradation, glycosphingolipid biosynthesis - globo series, glycosphingolipid biosynthesis - ganglio series, MPS VI - Maroteaux-Lamy syndrome, metabolic pathways, and lysosome pathways where it interacts with EIF2D, GYG1, CSNK2B, CHIA,CHIT1, and CHIT1 proteins.

Alternate Names

ENC-1AS, HCC-7, HEL-248, HEXB

Gene Symbol

HEXB

Additional Hexosaminidase B/HEXB Products

Product Documents for HEXB Antibody (HEXB/7762)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HEXB Antibody (HEXB/7762)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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