HEXB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48689

Novus Biologicals, part of Bio-Techne
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NBP2-48689
NBP2-48689-25ul
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Key Product Details

Validated by

Independent Antibodies

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Hexosaminidase B/HEXB Antibodies »

Product Summary for HEXB Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: PSVSAKPGPALWPLPLSVKMTPNLLHLAPENFYISHSPNSTAGPSCTLLEEAFRRYHGYI

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HEXB Antibody

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689]

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689]

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689] - Staining of human epididymis.
Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689]

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689]

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689] - Staining of human epididymis shows granular cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689]

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689]

Immunohistochemistry-Paraffin: HEXB Antibody [NBP2-48689] - Staining of human colon, epididymis, kidney and liver using Anti-HEXB antibody NBP2-48689 (A) shows similar protein distribution across tissues to independent antibody NBP2-49211 (B).
View 3 more images

Applications for HEXB Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Hexosaminidase B/HEXB

HEXB, also known as Beta-hexosaminidase subunit beta, is a 556 amino acid that is 63 kDa, lysosome located, composed of two subunits, alpha and beta, which are encoded by separate gene, and in control of the degradation of GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. Current research is being performed on several diseases and disorders including gangliosidosis, sandhoff disease, infantile, juvenile, and adult forms, tay-sachs disease, neuronitis, lysosomal storage disease, motor neuron disease, cervical cancer, mucopolysaccharidosis, cervicitis, neurodegenerative disease, recurrent respiratory papillomatosis, hairy cell leukemia, macrocephaly, autonomic dysfunction, cholesteatoma, type 2 diabetes mellitus, rheumatoid arthritis, and diarrhea. The protein has been linked to pathways such as glycan degradation, amino sugar and nucleotide sugar metabolism, glycosaminoglycan degradation, glycosphingolipid biosynthesis - globo series, glycosphingolipid biosynthesis - ganglio series, MPS VI - Maroteaux-Lamy syndrome, metabolic pathways, and lysosome pathways where it interacts with EIF2D, GYG1, CSNK2B, CHIA,CHIT1, and CHIT1 proteins.

Alternate Names

ENC-1AS, HCC-7, HEL-248, HEXB

Gene Symbol

HEXB

Additional Hexosaminidase B/HEXB Products

Product Documents for HEXB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HEXB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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