HIRA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38636

Novus Biologicals, part of Bio-Techne
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NBP2-38636
NBP2-38636-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HIRA Antibodies »

Product Summary for HIRA Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: LKLPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSRLKCNREGKEWETVLTSRILTAAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTLHC

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HIRA Antibody

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636]

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636]

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636] - Staining of human thyroid gland shows high expression.
Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636]

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636]

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636] - Staining of human liver shows low expression as expected.
Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636]

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636]

Immunohistochemistry-Paraffin: HIRA Antibody [NBP2-38636] - Staining in human thyroid gland and liver tissues using anti-HIRA antibody. Corresponding HIRA RNA-seq data are presented for the same tissues.

Applications for HIRA Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HIRA

HIRA encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq]

Alternate Names

DGCR1DiGeorge critical region gene 1, HIR, HIR (histone cell cycle regulation defective) homolog A (S. cerevisiae), HIR histone cell cycle regulation defective homolog A (S. cerevisiae), TUP1, TUP1-like enhancer of split protein 1, TUPLE1protein HIRA

Gene Symbol

HIRA

UniProt

P54198 (Human)

Additional HIRA Products

Product Documents for HIRA Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HIRA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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