Histone H1.2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49202

Novus Biologicals, part of Bio-Techne
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NBP2-49202
NBP2-49202-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Histone H1.2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: KKAGATAGKRKASGPPVSELITKAVAA

Reactivity Notes

Rat (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Histone H1.2 Antibody

Immunohistochemistry: Histone H1.2 Antibody [NBP2-49202]

Immunohistochemistry: Histone H1.2 Antibody [NBP2-49202]

Immunohistochemistry: Histone H1.2 Antibody [NBP2-49202] - Staining of human bone marrow shows strong nuclear positivity in hematopoietic cells.

Applications for Histone H1.2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Histone H1.2

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. The Histone H1.2 protein is 213 amino acids long, 21 kDA and is encoded by the HIST1H1C gene. H1 proteins are essential in forming chromatin fiber and for the condensation of nucleosome chains into higher-order structured fibers. The HIST1H1C gene has been investigated in leukemia and parkinson's disease. It plays a role in apoptosis, PKA signaling, cell cycle chromosome condensation in prometaphase, and histone modification through interactions with various genes such as TONSL, NPM1, YWHAQ, EED, and ESR2.

Alternate Names

H1 histone family, member 2, H1.2, H1F2H1C, histone 1, H1c, histone cluster 1, H1c, histone H1.2, Histone H1d, MGC3992

Gene Symbol

H1-2

Additional Histone H1.2 Products

Product Documents for Histone H1.2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Histone H1.2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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