Histone H1.5 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-17162

Novus Biologicals, part of Bio-Techne
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NBP3-17162-100ul
NBP3-17162-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Histone H1.5 Antibodies »

Product Summary for Histone H1.5 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: ETATPAPVEKSPAKKKATKKAAG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Histone H1.5 Antibody

Immunohistochemistry-Paraffin: Histone H1.5 Antibody [NBP3-17162]

Immunohistochemistry-Paraffin: Histone H1.5 Antibody [NBP3-17162]

Immunohistochemistry-Paraffin: Histone H1.5 Antibody [NBP3-17162] - Staining of human tonsil shows strong nuclear positivity in germinal- and non germinal center cells.

Applications for Histone H1.5 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Histone H1.5

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. Histone H1.5 is a 207 amino acid long, 22 kDA protein encoded by the gene HIST1H1B (found on chromosome 6p22-p21.3) that lacks polyA tails and instead obtain palindromic termination elements. H1 histones are critical for the condensation of nucleosome chains into higher order structures. HIST1H1B has been investigated regarding breast cancer, measles, ataxia, t-cell leukemia, arthritis, alzheimer's diseases, lupus, and prostate cancer. It is active in apoptosis, histone modification, PKA signaling, and cell cycle chromosome condensation in prometaphase as it interacts with genes H3F3A, H3F3B, SIRT1, CDK2, and L3MNTL1.

Alternate Names

H1, H1 histone family, member 5, H1.5, H1F5H1B, histone 1, H1b, histone cluster 1, H1b, histone H1.5, Histone H1a, MGC126630, MGC126632

Gene Symbol

HIST1H1B

Additional Histone H1.5 Products

Product Documents for Histone H1.5 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Histone H1.5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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