Histone H2AY/macroH2A.1 Antibody (RM248)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61494

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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NBP2-61494
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Key Product Details

Species Reactivity

Validated:

Human, Vertebrate

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Multiplex Immunoassay, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM248

Concentration

1 mg/ml

View all Histone H2AY Antibodies »

Product Summary for Histone H2AY/macroH2A.1 Antibody (RM248)

Immunogen

A peptide corresponding to the C-terminus of Human Histone H2AY/macroH2A.1

Specificity

This antibody reacts to Histone H2AY/macroH2A.1 protein, independent of post-translational modifications. No cross reactivity with other histone proteins.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Histone H2AY/macroH2A.1 Antibody (RM248)

Western Blot: Histone H2AY/macroH2A.1 Antibody (RM248) [NBP2-61494]

Western Blot: Histone H2AY/macroH2A.1 Antibody (RM248) [NBP2-61494]

Western Blot: Histone H2AY/macroH2A.1 Antibody (RM248) [NBP2-61494] - Western Blot of acid extracts from K562 cells, using NBP2-61494.
Immunocytochemistry/ Immunofluorescence: Histone H2AY/macroH2A.1 Antibody (RM248) [NBP2-61494]

Immunocytochemistry/ Immunofluorescence: Histone H2AY/macroH2A.1 Antibody (RM248) [NBP2-61494]

Immunocytochemistry/Immunofluorescence: Histone H2AY/macroH2A.1 Antibody (RM248) [NBP2-61494] - Immunocytochemistry of HeLa cells, using NBP2-61494 (red). Actin filaments have been labeled with fluorescein phalloidin (green).

Applications for Histone H2AY/macroH2A.1 Antibody (RM248)

Application
Recommended Usage

ELISA

0.2 ug/mL - 1 ug/mL

Immunocytochemistry/ Immunofluorescence

1 ug/ml - 2 ug/ml

Multiplex Immunoassay

0.2 ug/ml - 1 ug/ml

Western Blot

0.5 ug/ml - 2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Histone H2AY

macroH2A.1 (H2AFY) is 372 amino acids long, weighs approximately 40 kDa, and is part of a group of basic nuclear proteins called histones, which are responsible for nucleosome structure of the chromosomal fiber in eukaryotes. macroH2a.1 has two shorter isoforms meeasuring 371 and 369 amino acids long, both weighing approximately 39 kDa. Current studies are being done on several diseases and disorders including medulloblastoma, lupus erythematosus, Huntington's disease, immunodeficiency, melanoma, and malaria. macroH2A.1 has also been shown to have interactions with HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H4E in pathways such as the chromatin regulation/ acetylation, systemic lupus erythematosus, and ATF-2 transcription factor pathways.

Long Name

H2A Histone Family, Member Y

Alternate Names

H2AF12M, H2AFJ, H2AFY, Histone MacroH2A1, Medulloblastoma Antigen MU-MB-50.205

Gene Symbol

MACROH2A1

Additional Histone H2AY Products

Product Documents for Histone H2AY/macroH2A.1 Antibody (RM248)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Histone H2AY/macroH2A.1 Antibody (RM248)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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