HOX11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56424

Novus Biologicals, part of Bio-Techne
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NB100-56424
NB100-56424SS
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all HOX11 Antibodies »

Product Specifications

Immunogen

A peptide sequence corresponding to acids amino acids 306-318 (LQNLQPWSDDSTK) of human HOX11 was used as the immunogen.

Reactivity Notes

Predicted to react with Bovine, Chicken, Chimpanzee, Canine and Xenopus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HOX11 Antibody

Western Blot: HOX11 Antibody [NB100-56424]

Western Blot: HOX11 Antibody [NB100-56424]

Western Blot: HOX11 Antibody [NB100-56424] - Annalysis of HOX11 in A) human, B) mouse and C) rat liver cell lysate using NB100-56424 at 1 ug/ml.

Applications for HOX11 Antibody

Application
Recommended Usage

Western Blot

1-3 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HOX11

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Alternate Names

homeo box 11 (T-cell lymphoma 3-associated breakpoint), homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to DrosophilaNotch), Homeobox protein Hox-11, HOX11T-cell leukemia, homeobox 1, Proto-oncogene TCL-3, T-cell leukemia homeobox 1, T-cell leukemia homeobox protein 1, T-cell leukemia/lymphoma protein 3, TCL3MGC163402

Entrez Gene IDs

3195 (Human); 15396 (Mouse); 24452 (Rat)

Gene Symbol

TLX1

Additional HOX11 Products

Product Documents for HOX11 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HOX11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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