Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all HOX11 Antibodies »

Product Specifications

Immunogen

HOX11 antibody was raised against a 16 amino acid peptide near the amino terminus of human HOX11. The immunogen is located within the first 50 amino acids of HOX11. Amino Acid Squence: MGPASRKQDGEYGLG

Specificity

Multiple isoforms of HOX11 exist due to alternative splicing events. HOX11 antibody is predicted to not cross-react with other TLX proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

35 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for HOX11 Antibody - BSA Free

Western Blot: HOX11 AntibodyBSA Free [NBP2-81887]

Western Blot: HOX11 AntibodyBSA Free [NBP2-81887]

Western Blot: HOX11 Antibody [NBP2-81887] - Analysis of HOX11 in mouse spleen tissue lysate with HOX11 antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry: HOX11 Antibody - BSA Free [NBP2-81887]

Immunohistochemistry: HOX11 Antibody - BSA Free [NBP2-81887]

Immunohistochemistry: HOX11 Antibody [NBP2-81887] - Analysis of HOX11 in human spleen tissue with HOX11 antibody at 2.5 ug/ml.

Applications for HOX11 Antibody - BSA Free

Application
Recommended Usage

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HOX11

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Alternate Names

homeo box 11 (T-cell lymphoma 3-associated breakpoint), homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to DrosophilaNotch), Homeobox protein Hox-11, HOX11T-cell leukemia, homeobox 1, Proto-oncogene TCL-3, T-cell leukemia homeobox 1, T-cell leukemia homeobox protein 1, T-cell leukemia/lymphoma protein 3, TCL3MGC163402

Gene Symbol

TLX1

Additional HOX11 Products

Product Documents for HOX11 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HOX11 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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