Human Activin RIIB Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB3393
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 Clone # 60402
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # Q13705
Ser19-Thr134
Accession # Q13705
Specificity
Detects human Activin RIIB in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human Activin RIIA is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for Human Activin RIIB Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RB)
Sample: Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RB)
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Reviewed Applications
Read 1 review rated 5 using MAB3393 in the following applications:
Formulation, Preparation, and Storage
Purification
Protein A or G purified from ascites
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Activin RIIB
Members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor‑beta (TGF‑beta) family members, including Activin, Nodal, Bmp7, Gdf1, Gdf3, Myostatin (Gdf8), and Gdf11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated. Human, mouse and rat activin RIIB share greater than 98% amino acid sequence homology.
Long Name
Activin Receptor IIB
Alternate Names
ActivinRIIB, ACVR2B
Gene Symbol
ACVR2B
UniProt
Additional Activin RIIB Products
Product Documents for Human Activin RIIB Antibody
Product Specific Notices for Human Activin RIIB Antibody
For research use only
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