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Human Angiopoietin-like Protein 1/
ANGPTL1 Antibody

R&D Systems, part of Bio-Techne | Catalog # AF2204

R&D Systems, part of Bio-Techne
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AF2204
AF2204-SP

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Angiopoietin-like 1/ANGPTL1
Ala39-Asp491
Accession # O95841

Specificity

Detects human Angiopoietin-like 1/ANGPTL1 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross‑reactivity with recombinant mouse Angiopoietin-like 1/ANGPTL1, recombinant human Angiopoietin-like 2/ANGPTL2 and recombinant human Angiopoietin-like 6/ANGPTL6 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Human Angiopoietin-like Protein 1/ANGPTL1 Antibody

Detection of Angiopoietin-like Protein 1/ANGPTL1 in Human Placenta.

Angiopoietin-like Protein 1/ANGPTL1 was detected in immersion fixed paraffin-embedded sections of Human Placenta using Goat Anti-Human Angiopoietin-like Protein 1/ANGPTL1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2204) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to vascular endothelial cells in chorionic villi. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Applications for Human Angiopoietin-like Protein 1/ANGPTL1 Antibody

Application
Recommended Usage

Immunohistochemistry

3-15 µg/mL
Sample: Immersion fixed paraffin-embedded sections of Human Placenta

Western Blot

0.1 µg/mL
Sample: Recombinant Human Angiopoietin-like 1

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Angiopoietin-like Protein 1/ANGPTL1

Angiopoietin-like 1 is a secreted glycoprotein structurally related to the angiopoietins. It contains an N-terminal coiled-coiled domain and a C-terminal fibrinogen-like domain. Unlike angiopoietins which are agonists and antagonists of the Tie-2 receptor tyrosine kinase, Angiopoietin-like 1 is an orphan ligand that does not bind Tie-2.

Alternate Names

Angiopoietin like Protein 1, ANGPTL1, AngY1, ARP1

Entrez Gene IDs

9068 (Human); 72713 (Mouse); 679942 (Rat)

Gene Symbol

ANGPTL1

UniProt

Additional Angiopoietin-like Protein 1/ANGPTL1 Products

Product Documents for Human Angiopoietin-like Protein 1/ANGPTL1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Angiopoietin-like Protein 1/ANGPTL1 Antibody

For research use only

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