Human Complement Factor H-related 1/CFHR1 Antibody
R&D Systems, part of Bio-Techne | Catalog # AF4247
Key Product Details
Species Reactivity
Human
Applications
Immunoprecipitation, Western Blot
Label
Unconjugated
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 1/CFHR1
Glu19-Ala328
Accession # Q03591
Glu19-Ala328
Accession # Q03591
Specificity
Detects human Complement Factor H-related 1/CFHR1 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross‑reactivity with recombinant human (rh) FHR2 is observed and approximately 15% cross-reactivity with rhFHR5 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human Complement Factor H-related 1/CFHR1 Antibody
Application
Recommended Usage
Immunoprecipitation
25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human
Complement Factor H-related 1/CFHR1, see our available Western blot detection antibodies
Sample: Conditioned cell culture medium spiked with Recombinant Human
Complement Factor H-related 1/CFHR1, see our available Western blot detection antibodies
Western Blot
0.1 µg/mL
Sample: Recombinant Human Complement Factor H-related 1/CFHR1
Sample: Recombinant Human Complement Factor H-related 1/CFHR1
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Complement Factor H-related 1/CFHR1
FHR1 (Complement Factor H-related protein 1) is a 43 kDa, secreted member of the factor H family of glycoproteins. It is produced by hepatocytes and circulates as two differentially glycosylated isoforms (37 kDa and 43 kDa). Mature human FHR1 is 312 amino acids (aa) in length. It contains five, approximately 60 aa SCRs (short consensus repeats/CCPs/SUSHI repeats) that basically constitute the entire molecule. FHR1 may play a role in lipoprotein complexes that bind PMNs to LPS. There is no reported rodent counterpart to FHR1. Over aa 19‑143 of the FHR1 precursor, human FHR2 and FHR5 show 98% and 86% aa identity, respectively.
Alternate Names
BTA, CFHR1, Complement Factor Hrelated 1, FHR1
Entrez Gene IDs
3078 (Human)
Gene Symbol
CFHR1
UniProt
Additional Complement Factor H-related 1/CFHR1 Products
- All Products for Complement Factor H-related 1/CFHR1
- Complement Factor H-related 1/CFHR1 cDNA Clones
- Complement Factor H-related 1/CFHR1 ELISA Kits
- Complement Factor H-related 1/CFHR1 Lysates
- Complement Factor H-related 1/CFHR1 Primary Antibodies
- Complement Factor H-related 1/CFHR1 Proteins and Enzymes
Product Documents for Human Complement Factor H-related 1/CFHR1 Antibody
Product Specific Notices for Human Complement Factor H-related 1/CFHR1 Antibody
For research use only
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