Human CRHR-1 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB3930
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Hamster - Cricetulus (Chinese Hamster)
Applications
Validated:
CyTOF-ready, Flow Cytometry, Immunohistochemistry
Cited:
Immunohistochemistry
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # 343919
Product Specifications
Immunogen
NS0 mouse myeloma cell line transfected with human CRHR-1
Ser24-Val415
Accession # NP_004373
Ser24-Val415
Accession # NP_004373
Specificity
Detects human CRHR‑1 transfectants but not irrelevant transfectants.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Human CRHR-1 Antibody
Application
Recommended Usage
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Flow Cytometry
2.5 µg/106 cells
Sample: Human CRHR‑1 transfected Ba/F3 cells
Sample: Human CRHR‑1 transfected Ba/F3 cells
Immunohistochemistry
8-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human placenta
Sample: Immersion fixed paraffin-embedded sections of human placenta
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CRHR1
Corticotrophin-Releasing Hormone Receptor 1 (CRHR-1), also known as CRFR-1, is a 7TM protein that belongs to the G protein-coupled receptor family 2. CRHR-1 is expressed in the brain and adrenal gland where it mediates corticotropin-induced effects on anxiety, depression, and stress-associated pathologies. The immunogen for this antibody corresponds to one of the four alternately spliced forms and has a 29 amino acid deletion in the first cytoplasmic domain. Human CRHR-1 shares 97% amino acid sequence identity with mouse and rat CRHR-1.
Long Name
Corticotropin Releasing Hormone Receptor 1
Alternate Names
CHR-R1, CRF1, CRFR, CRFR1
Gene Symbol
CRHR1
UniProt
Additional CRHR1 Products
Product Documents for Human CRHR-1 Antibody
Product Specific Notices for Human CRHR-1 Antibody
For research use only
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