Human ERR beta/NR3B2 Antibody
R&D Systems, part of Bio-Techne | Catalog # PP-H6705-00
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human, Mouse
Applications
Validated:
Immunohistochemistry, Immunoprecipitation, Western Blot
Cited:
Bioassay, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # H6705
Product Specifications
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Scientific Data Images for Human ERR beta/NR3B2 Antibody
Detection of Mouse ERR beta/NR3B2 by Immunocytochemistry/Immunofluorescence
Immediate firing motoneurons, but not delayed firing motoneurons, express ERR beta.(A) Examples of Err beta. staining (red) in neurobiotin (green) filled motoneurons. The arrowhead in the first row points to the nucleus (Err beta−positive) of the recorded motoneuron. The asterisk in the second row indicates that the nucleus of the recorded motoneuron was Err beta−negative. (B) Plot of the AHP relaxation time constants against the rheobases for labelled motoneurons. All immediate firing motoneurons were Err beta−positive whereas all delayed firing motoneurons were Err beta−negative. Arrowheads point to the motoneurons illustrated in A.DOI:https://dx.doi.org/10.7554/eLife.04046.008 Image collected and cropped by CiteAb from the following publication (https://elifesciences.org/articles/04046), licensed under a CC-BY license. Not internally tested by R&D Systems.Applications for Human ERR beta/NR3B2 Antibody
Application
Recommended Usage
Immunohistochemistry
5-15 µg/mL
Sample: Perfusion fixed paraffin-embedded sections of rat kidney
Sample: Perfusion fixed paraffin-embedded sections of rat kidney
Immunoprecipitation
Western Blot
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: ERR beta/NR3B2
Estrogen-related receptor alpha (ERR-alpha, ERR1, ESRL1; NR3B1) is a member of the orphan nuclear receptor family. ERR-alpha is expressed in the liver, kidney, brain, heart, uterus, vagina and cervix. ERR-alpha takes part in the cell cycle and the fatty acid metabolizing of the musculus skeleti. ERR-alpha was shown to interact with ER-alpha. ERR-beta (ERR2; NR3B2) is also expressed in the liver, brain, uterus, vagina, and cervix. ERR-beta has a role in early placental development. ERR-gamma (ESRRG; NR3B3) is expressed in the brain, kidney, testis, lung, adrenal gland, pancreas, placenta and bone marrow. ERR-gamma was shown to be located in the critical region for Usher's syndrome.
Long Name
Estrogen-related Receptor beta
Alternate Names
ERR2, ESRL2, ESRRB, NR3B2
Entrez Gene IDs
2103 (Human)
Gene Symbol
ESRRB
Additional ERR beta/NR3B2 Products
Product Documents for Human ERR beta/NR3B2 Antibody
Product Specific Notices for Human ERR beta/NR3B2 Antibody
For research use only
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