Human Kremen-1 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB2127
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 Clone # 301324
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kremen‑1
Ala20-Gly397
Accession # NP_114434
Ala20-Gly397
Accession # NP_114434
Specificity
Detects human Kremen-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse Kremen-1 or recombinant human Kremen-2 is observed.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for Human Kremen-1 Antibody
Application
Recommended Usage
Western Blot
1 µg/mL
Sample: Recombinant Human Kremen-1
Sample: Recombinant Human Kremen-1
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Kremen-1
Kremen-1 is a type I transmembrane protein that contains extracellular Kringle, WSC, and CUB domains. It is expressed in diverse embryonic and adult tissues. Kremen proteins bind the secreted Dickkopf proteins Dkk-1, -2, and -4 with high affinity to antagonize the canonical Wnt signaling pathway.
Long Name
Kringle-containing Transmembrane Protein 1
Alternate Names
Kremen1, KRM1
Gene Symbol
KREMEN1
UniProt
Additional Kremen-1 Products
Product Documents for Human Kremen-1 Antibody
Product Specific Notices for Human Kremen-1 Antibody
For research use only
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