Human LRH-1/NR5A2 Antibody
R&D Systems, part of Bio-Techne | Catalog # PP-K8801-00
Key Product Details
Species Reactivity
Human
Applications
Immunoprecipitation, Western Blot
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2A Clone # K8801
Product Specifications
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2A
Applications for Human LRH-1/NR5A2 Antibody
Application
Recommended Usage
Immunoprecipitation
Western Blot
Formulation, Preparation, and Storage
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: LRH-1/NR5A2
Liver receptor homolog-1 (LRH-1, FTF, CPF, hB1F, FTZ-F1b; NR5A2) is a member of the orphan nuclear receptor family. LRH-1 is a mammalian homolog of the Drosophila fushi tarazu Factor 1 gene product. LRH-1 is thought to be critical for development because LRH-1 knockout mice are not viable. LRH-1 is expressed in the liver, intestine, pancrease, ovary and preadipocytes.
LRH-1 is involved in the regulation of genes which participate in steroid, bile acid and cholesterol homeostasis. A role for LRH-1 in steroidogenesis is supported by its expression in ovarian granulosa cells and corpus luteum. LRH-1 has been shown to regulate transcription of several steroidogenic genes and is known to modulate the expression of aromatase in breast adipose tissue.
Long Name
Liver Receptor Homolog 1/Nuclear Receptor Subfamily 5, Group A, Member 2
Alternate Names
B1F2, FTZ-F1 beta, LRH1, NR5A2
Entrez Gene IDs
2494 (Human)
Gene Symbol
NR5A2
Additional LRH-1/NR5A2 Products
Product Documents for Human LRH-1/NR5A2 Antibody
Product Specific Notices for Human LRH-1/NR5A2 Antibody
For research use only
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